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The historical nature of macroevolutionary study involves inference from fossils and DNA rather than direct observation. Yet in the historical sciences (which include astronomy, geology and archaeology, as well as evolutionary biology), hypotheses can still be tested by checking whether they accord with physical evidence and whether they lead to verifiable predictions about future discoveries. For instance, evolution implies that between the earliest-known ancestors of humans (roughly five million years old) and the appearance of anatomically modern humans (about 100,000 years ago), one should find a succession of hominid creatures with features progressively less apelike and more modern, which is indeed what the fossil record shows. But one should not--and does not--find modern human fossils embedded in strata from the Jurassic period (144 million years ago). Evolutionary biology routinely makes predictions far more refined and precise than this, and researchers test them constantly.

Evolution could be disproved in other ways, too. If we could document the spontaneous generation of just one complex life-form from inanimate matter, then at least a few creatures seen in the fossil record might have originated this way. If superintelligent aliens appeared and claimed credit for creating life on earth (or even particular species), the purely evolutionary explanation would be cast in doubt. But no one has yet produced such evidence.

It should be noted that the idea of falsifiability as the defining characteristic of science originated with philosopher Karl Popper in the 1930s. More recent elaborations on his thinking have expanded the narrowest interpretation of his principle precisely because it would eliminate too many branches of clearly scientific endeavor.

...but was frustrated when at just a touch the skull crumbled to dust, and the other bones likewise broke into pieces.