Citat:
Ursprungligen postat av
akitokraN
Say how? Någon guide?

Vad du behöver är i stort sett vinsyra:
https://sv.wikipedia.org/wiki/Vinsyra
Eller dextro-vinsyra, för att vara exakt
Saxar direkt ur en fin liten bok jag har här, kallad Pharmaceutical Manufacturing Encyclopedia av Marshall Sittig. OT, vet någon var man kan ladda ner Volym 3 respektive Sittigs andra böcker får denne någon gärna PM mig om det
"Manufacturing Process
Two mols, for example, 270 grams, of racemic α-methylphenethylamine base are reacted with one mole (150 grams) of d-tartaric acid, thereby forming dl-a-methylphenethylamine d-tartrate, a neutral salt. The neutral salt thus obtained is fully dissolved by the addition of sufficient, say about 1 liter, of absolute ethanol, and heating to about the boiling point. The solution is then allowed to cool to room temperature with occasional stirring to effect crystallization. The crystals are filtered off and will be found to contain a preponderance of the levo enantiomorph.
The residual solid in the mother liquors is repeatedly and systematically crystallized, yielding a further fraction of 1-a-methylphenethylamine d-tartrate which may be purified by recrys- tallization. d-a-Methylphenethylamine may be readily recovered from the mother liquors
by the addition of tartaric acid thereto for the formation of acid tartrates and separation
of d-a-methylphenethylamine d-bitartrate by crystallization.
The free base of either optical isomer may be obtained by addition to the d-tartrate in the case of the levo isomer and the d-bitartrate in the case of the dextro isomer of alkali in excess, as, for example, by the addition of an aqueous solution of caustic soda, which will cause the base to separate as an oil which may be recovered and purified by any well-known procedure. The base is exactly neutralized with sulfuric acid to give the sulfate."
References
Merck Index 2918
PDR pp. 1450,1711
OCDSVol. 1 p. 70 (1977)
I.N.p.301
REM p. 881
Nabenhauer, F.P.;U.S. Patent 2,276,508; March 17, 1942; assigned to Smith, Kline & French
Laboratories
Förenklat:
1.Basa saltet.
2. Separera fribasen från vattnet.
3. Lös fribasen i alkohol (helst anhydröst etanol, men metanol funkar fint det också)
4. Tillsätt 0.5 mol d-vinsyra per 1 mol amfetamin.
5. Agitera och kyl ned.
6. Filtrera av l-amfetamin-d-tartratet som faller ut.
7. Basa metanolet.
8. Extrahera d-amfetaminfribasen med valfritt opolärt lösningsmedel (ex. bensen, toluen, xylen, eter eller klorofom. De två senare påstås, enligt säkra källor, vara vanliga upphov till "kletigheten" i pasta).
9. Tillsätt 1 mol svavelsyra löst i, helst, 9-19gånger sin volym alkohol till extraktet från punkt 8.
10. Filtrera och låt d-amfetaminsulfatet torka.
11. Ha så kul!