En ny studie har publicerats och resultaten i studien visar att lågkolhydratkost verkar påverka energiförbrukningen, större kcal-skillnad för de med högre insulinsekretion, mindre kcal-skillnad för de med lägre insulinsekretion. Detta ger alltså ett visst stöd till LCHF-arnas utskrattade och hånade teori rörande insulin och energiförbrukning. Ghrelin-nivåerna var även lägre bland de som åt lågkolhydrat-kost så man kan tänka sig att den gruppen eventuellt kände sig mer mätta, i och för sig så var även leptin-nivåerna lägre i den gruppen så det är inte alls säkert.
"Results Total energy expenditure differed by diet in the intention-to-treat analysis (n=162, P=0.002), with a linear trend of 52 kcal/d (95% confidence interval 23 to 82) for every 10% decrease in the contribution of carbohydrate to total energy intake (1 kcal=4.18 kJ=0.00418 MJ). Change in total energy expenditure was 91 kcal/d (95% confidence interval −29 to 210) greater in participants assigned to the moderate carbohydrate diet and 209 kcal/d (91 to 326) greater in those assigned to the low carbohydrate diet compared with the high carbohydrate diet. In the per protocol analysis (n=120, P<0.001), the respective differences were 131 kcal/d (−6 to 267) and 278 kcal/d (144 to 411). Among participants in the highest third of pre-weight loss insulin secretion, the difference between the low and high carbohydrate diet was 308 kcal/d in the intention-to-treat analysis and 478 kcal/d in the per protocol analysis (P<0.004). Ghrelin was significantly lower in participants assigned to the low carbohydrate diet compared with those assigned to the high carbohydrate diet (both analyses). Leptin was also significantly lower in participants assigned to the low carbohydrate diet (per protocol).
Conclusions Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion."
"Conclusions and policy implications:
Dietary composition seems to affect energy expenditure independently of body weight. A low glycemic load, high fat diet might facilitate weight loss maintenance beyond the conventional focus on restricting energy intake and encouraging physical activity. Additional research is warranted to examine the effects of glycemic load on body weight, with control of energy intake; to compare diets aiming to reduce glycemic index at prevailing carbohydrate levels (eg, the DIETFITS lower fat diet) compared with restricting total carbohydrate; to explore subgroup susceptibility based on insulin secretion and other biological factors; to determine whether extreme carbohydrate restriction (eg, with a ketogenic diet) confers unique advantages for obesity or specific conditions such as diabetes; and to explore the mechanisms relating dietary composition to energy expenditure. If metabolic benefits of reduced glycemic load diets are confirmed, development of appropriate behavioral and environmental interventions would be necessary for optimal translation to public health."
"What is already known on this topic:
-Energy expenditure declines with weight loss, predisposing to weight regain.
-Little is, however, known about how dietary composition influences this adaptive metabolic response over the long term.
What this study adds:
-A low carbohydrate diet could increase energy expenditure during weight loss maintenance.
-This metabolic effect could improve the effectiveness of obesity treatment."
https://www.bmj.com/content/363/bmj.k4583
"Results Total energy expenditure differed by diet in the intention-to-treat analysis (n=162, P=0.002), with a linear trend of 52 kcal/d (95% confidence interval 23 to 82) for every 10% decrease in the contribution of carbohydrate to total energy intake (1 kcal=4.18 kJ=0.00418 MJ). Change in total energy expenditure was 91 kcal/d (95% confidence interval −29 to 210) greater in participants assigned to the moderate carbohydrate diet and 209 kcal/d (91 to 326) greater in those assigned to the low carbohydrate diet compared with the high carbohydrate diet. In the per protocol analysis (n=120, P<0.001), the respective differences were 131 kcal/d (−6 to 267) and 278 kcal/d (144 to 411). Among participants in the highest third of pre-weight loss insulin secretion, the difference between the low and high carbohydrate diet was 308 kcal/d in the intention-to-treat analysis and 478 kcal/d in the per protocol analysis (P<0.004). Ghrelin was significantly lower in participants assigned to the low carbohydrate diet compared with those assigned to the high carbohydrate diet (both analyses). Leptin was also significantly lower in participants assigned to the low carbohydrate diet (per protocol).
Conclusions Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion."
"Conclusions and policy implications:
Dietary composition seems to affect energy expenditure independently of body weight. A low glycemic load, high fat diet might facilitate weight loss maintenance beyond the conventional focus on restricting energy intake and encouraging physical activity. Additional research is warranted to examine the effects of glycemic load on body weight, with control of energy intake; to compare diets aiming to reduce glycemic index at prevailing carbohydrate levels (eg, the DIETFITS lower fat diet) compared with restricting total carbohydrate; to explore subgroup susceptibility based on insulin secretion and other biological factors; to determine whether extreme carbohydrate restriction (eg, with a ketogenic diet) confers unique advantages for obesity or specific conditions such as diabetes; and to explore the mechanisms relating dietary composition to energy expenditure. If metabolic benefits of reduced glycemic load diets are confirmed, development of appropriate behavioral and environmental interventions would be necessary for optimal translation to public health."
"What is already known on this topic:
-Energy expenditure declines with weight loss, predisposing to weight regain.
-Little is, however, known about how dietary composition influences this adaptive metabolic response over the long term.
What this study adds:
-A low carbohydrate diet could increase energy expenditure during weight loss maintenance.
-This metabolic effect could improve the effectiveness of obesity treatment."
https://www.bmj.com/content/363/bmj.k4583
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Senast redigerad av SecularScience 2018-11-15 kl. 15:47.
Senast redigerad av SecularScience 2018-11-15 kl. 15:47.