Citat:
Ursprungligen postat av
arbetet
COVID19-sjuka med den brittiska mutationen har 32% till 104% större risk att dö. Ny rapport i British Medical Journal:
Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study
Abstract
Objective To establish whether there is any change in mortality from infection with a new variant of SARS-CoV-2, designated a variant of concern (VOC-202012/1) in December 2020, compared with circulating SARS-CoV-2 variants.
Design Matched cohort study.
Setting Community based (pillar 2) covid-19 testing centres in the UK using the TaqPath assay (a proxy measure of VOC-202012/1 infection).
Participants 54 906 matched pairs of participants who tested positive for SARS-CoV-2 in pillar 2 between 1 October 2020 and 29 January 2021, followed-up until 12 February 2021. Participants were matched on age, sex, ethnicity, index of multiple deprivation, lower tier local authority region, and sample date of positive specimens, and differed only by detectability of the spike protein gene using the TaqPath assay.
Main outcome measure Death within 28 days of the first positive SARS-CoV-2 test result.
Results The mortality hazard ratio associated with infection with VOC-202012/1 compared with infection with previously circulating variants was 1.64 (95% confidence interval 1.32 to 2.04) in patients who tested positive for covid-19 in the community. In this comparatively low risk group, this represents an increase in deaths from 2.5 to 4.1 per 1000 detected cases.
Conclusions The probability that the risk of mortality is increased by infection with VOC-202012/01 is high. If this finding is generalisable to other populations, infection with VOC-202012/1 has the potential to cause substantial additional mortality compared with previously circulating variants. Healthcare capacity planning and national and international control policies are all impacted by this finding, with increased mortality lending weight to the argument that further coordinated and stringent measures are justified to reduce deaths from SARS-CoV-2.
https://www.bmj.com/content/372/bmj.n579
Att dödligheten inte stuckit iväg trots att den brittiska varianten varit dominerande länge talar ju emot det faktumet.
Det har kommit uppskattningar i den sfären tidigare. Det kan säkert vara viss variation mot andra varianter. En brist jag ser det är att när man matchat paren har man tagit med variabler som kön, ålder och etnicitet men ingenting om hälsotillstånd. Kanske för att fakta inte var tillgänglig, men underliggande sjukdomar är nog den avgörande variabeln oavsett mutationsvariant.
