* Poppers are used by sniffing the vapors from an open bottle. The effects are felt within a few seconds and last for 1-2 minutes.
* Poppers cause muscles around blood vessels to relax, making your heart speed up to pump more blood. Oxygen-rich blood reaching the brain produces a "rush" sensation.
* Because poppers cause muscles in the anus and vagina to relax, they are often used during sex.