Beskrivs i termer av barbiturater med därtill dissociativ-psykedelisk effekt påminnandes of PCP. Möjligen AMPA-antagonist utöver reguljär NMDA-blockad? Jag tycker den verkar extremt spännande. Nu vill en dock inte erfara om den dämpar andningsmuskulatur eller ö.h.t. är en CNS-depressant likt barbiturater
den hårda vägen. Ta det lugnt med doserna tills vi vet?
EDIT: Tänker alltså främst på Rolicyklidin.
Citat:
Rolicyclidine (PCPy) is a dissociative anesthetic that is similar in effects to phencyclidine, but is slightly less potent and has fewer stimulant effects.[2] It instead produces a sedative effect described as being somewhat similar to a barbiturate, but with additional PCP-like dissociative, anaesthetic and hallucinogenic effects.[3]
https://en.m.wikipedia.org/wiki/Rolicyclidine
Citat:
In addition to this GABAergic effect, barbiturates also block AMPA and kainate receptors, subtypes of ionotropic glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS.
https://en.m.wikipedia.org/wiki/Barbiturate