Gick själv på tramadol dagligen i över 6 års tid. Redan då jag höll på så funderade jag på vika ev skador på ens kropp som kunde uppstå pga denna användning. Jag är nyfiken på ämnet.
Finns det någon information på hur t ex tramdol på sikt påverkar kroppens inre organ - lever , njurar, hjärta ?
Med tanke på i vilken omfattning folk ändå missbrukar såna här preparat tycker jag det finns ganska lite information om det
Ibland när man läser om nån som dött, så kan man läsa t ex att nån som gått på smärtstillande har förstorat hjärta. Är det en biverkning av vissa smärtstillande? Hur är det med leverpåverkan? Påverkan på det kardiovaskulära?
Ställer frågan allmänt för alla typer av opioider inte bara tramadol.
Vet ju att enligt myten så ska rent morfin inte alls skada kroppen på minsta sätt förutom vid överdos. Men jag vet inte hurpass väl den stämmer. Dock är ju inte rent morfin och opioider samma sak.
= Morfin betydligt farligare än tramadol. Samtliga parametrar var förhöjda jämfört med kontrollgrupp. Tramadolgruppen hade endast ALT som var förhöjt men histologiskt kunde inget patologiskt hittas.
opioid therapy was associated with a 77% increased risk of cardiovascular events (eg, myocardial infarction, heart failure). In the first 30 days, the risk of cardiovascular events was similar across different opioid medications. However, after 180 days of therapy, codeine was associated with a 62% increase in these adverse events as compared to hydrocodone.11,12 Another large cohort study based on health insurance claims also showed increased risks of myocardial infarction and cardiovascular revascularization among patients on chronic opioid therapy relative to the general population.26 These findings of adverse cardiovascular effects to opioids may be explained by potential biases in observational research and need to be replicated, but it cannot be assumed that opioids have lower cardiotoxicity than COX-2 inhibitors in the absence of adequate empirical research to support such a conclusion.
Endokrina effekter
Chronic opioid therapy has been found to have a strong impact on the male and female endocrine system. The mechanism of these effects is believed to occur through opiate interaction with the hypothalamic-pituitary-adrenal axis in humans. Opiates have been shown to affect the release of every hormone from the anterior pituitary including growth hormone, prolactin, thyroid-stimulating hormone, adrenocorticotropic hormone, and lutein-stimulating hormone.41 Individuals on chronic opioid therapy have been shown to have a hyperfunctioning hypothalamic-pituitary-adrenal axis accompanied by decreased functioning of the hypothalamic-pituitary-gonadal axis. Of all of the endocrinopathies observed, some of the most profound pertain to the decrease of gonadotropin-releasing hormone.42 This decrease in gonadotropin-releasing hormone can manifest clinically in males as hypogonadism, also known as opiate-induced androgen deficiency, sexual dysfunction, infertility, fatigue, and decreased levels of testosterone.43 The decrease in testosterone is of special concern because preliminary studies have suggested increased risk of metabolic syndrome and insulin resistance.41
The decreased pulsatile release of gonadotropin-releasing hormone and subsequent decrease in luteinizing and follicle-stimulating hormones may have dramatic clinical consequences in women as well. Decreased circulating levels of estrogen, low follicle-stimulating hormone, and increased prolactin can lead to osteoporosis, oligomenorrhea, and galactorrhea.41 These preliminary findings suggest the need for caution when prescribing to patients with existing conditions such as osteopenia. It has been noted that these side effects are reversible with cessation of treatment or lower dosing.44
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Senast redigerad av 09GR 2020-08-17 kl. 00:00.
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