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Ursprungligen postat av PlusFifty
Exakt detta r tidigare kommenterat av Qidush (en mkt kunnig FB:are) och enligt uppgift kan aldrig en signalsubstans binda till andra receptorer n de som r avsedda fr just den substansen. Detta stmmer ocks med den information jag sjlv lyckats hitta p ntet. Den som pstr det du pstr i detta inlgg br verifiera pstendet med tillfrlitlig klla...tills dess s kommer i alla fall jag ha uppfattningen att detta med "frtningen" r ngn form av skrmselpropaganda som saknar vetenskaplig grund.
Ta inte detta personligen, ditt inlgg r jttebra och det r precis s hr ett forum ska anvndas - uppfattningar, bemtande och diskussioner!
Finns bland annat det hr att lsa:
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In the case of MDMA, which is only neurotoxic to 5-HT terminals, it is believed that the excessive DA released in the synapse can be either taken up by the activated 5-HT transporter into the terminals or synthesized nonenzymatically inside the terminals from tyrosine, where it subsequently generates free radicals and produces oxidative damage
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One proposed mechanism for MDMA neurotoxicity is that after ingestion, MDMA breaks down into a variety of metabolites, some of which are highly reactive molecules called free radicals'. Unless properly handled by the brain, these free radicals will damage neurons through a process called oxidative stress'. If MDMA concentrations remain high enough for a long enough period of time, the neurons' capacity for processing these metabolites fails, though if doses are low enough, the brain is able to keep up and no damage occurs. Another theory, by Nichols at Purdue, is that the free radicals result from an abnormal metabolism of dopamine.
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The exact mechanism of MDMA neurotoxicity in animals is not presently known [11], but it seems to require dopamine activity, oxidation, and access to the 5-HT transporter. Increasing dopamine activity via ingestion of methamphetamine, l-tyrosine, phenylalanine or l-dopa would tend to increase MDMA neurotoxicity
Mycket r taget frn bland annat
http://www.erowid.org/chemicals/mdma/
Finns ven en bra sida som frklarar ganska ingende hr, utan att man behver kunna allt fr mycket facktermer p engelska.
http://www.dancesafe.org/slideshow/slide19.html
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The most current theory of how MDMA causes neurotoxic damage in laboratory animals goes like this:
After MDMA depletes serotonin, the reuptake transporters are left vacant and exposed. When this happens, dopamine enters the transporter and gets taken up into the serotonin axon, where it isn't supposed to be. Studies have shown that dopamine itself is toxic to serotonin cells. But if that weren't enough, MAO comes along and breaks it down into hydrogen peroxide, which is also toxic to the cell. (Yes, the same hydrogen peroxide they put in hair bleach!) The hydrogen peroxide then "oxidizes" certain parts of the cell which don't normally get oxidized ("oxidize," as used here, basically means to break down with oxygen). Researchers sometimes refer to this as oxidative stress, and a number of studies have looked at anti-oxidants like Vitamin-C as a possible agent to prevent MDMA's neurotoxicity
Frvrigt vet man inte 100% skert vad det r som orsakar den sortens toxicitet, men det finns mycket som pekar mot att de teorier som finns r riktiga.
