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"Låga" off-label doser av kvetiapin för sömn brukar vara 25-50 mg. Den lägsta studien som har gjorts är på 12,5 mg.
1. https://en.wikipedia.org/wiki/Quetiapine#:~:text=Quetiapine%2C%20sold%20under%20 the%20brand,disorder%2C%20and%20major%20depressive %20disorder.
2. https://www.fass.se/LIF/product?userType=2&nplId=20080925000013&docType=3& scrollPosition=567.1751098632812
Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use may not outweigh its undesirable side effects.
Quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties.
Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor.
Peak levels of quetiapine occur 1.5 hours after a dose. The major active metabolite of quetiapine is norquetiapine. Quetiapine has an elimination half-life of 6 or 7 hours. Its metabolite, norquetiapine, has a half-life of 9 to 12 hours.
At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker.[/b]
It is on the World Health Organization's List of Essential Medicines. Doses of quetiapine used for insomnia have ranged from 12.5 to 800 mg, with low doses of 25 to 200 mg being the most typical.
Regardless of the dose used, some of the more serious adverse effects may still possibly occur at the lower dosing ranges, such as dyslipidemia and neutropenia.
Quetiapine is sometimes associated with drug misuse and abuse potential, for its hypnotic and sedative effects.
2. https://www.fass.se/LIF/product?userType=2&nplId=20080925000013&docType=3& scrollPosition=567.1751098632812
Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use may not outweigh its undesirable side effects.
Quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties.
Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor.
Peak levels of quetiapine occur 1.5 hours after a dose. The major active metabolite of quetiapine is norquetiapine. Quetiapine has an elimination half-life of 6 or 7 hours. Its metabolite, norquetiapine, has a half-life of 9 to 12 hours.
At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker.[/b]
It is on the World Health Organization's List of Essential Medicines. Doses of quetiapine used for insomnia have ranged from 12.5 to 800 mg, with low doses of 25 to 200 mg being the most typical.
Regardless of the dose used, some of the more serious adverse effects may still possibly occur at the lower dosing ranges, such as dyslipidemia and neutropenia.
Quetiapine is sometimes associated with drug misuse and abuse potential, for its hypnotic and sedative effects.
Kvetiapin rekommenderas inte för sömn även om den används flitigt men på vilka doser grundas dessa rekommendationer, och gäller det oavsett hur låga doser som tas?
Vilka negativa biverkningar kan förväntas vid exempelvis en åttondel av en 25 mg tablett (ca 3 mg) per natt?