sodastream (lustgas)

Hemoglobin, the main oxygen-carrying molecule in red blood cells, can carry both oxygen and carbon dioxide, although in quite different ways. The decreased binding to oxygen in the blood due to increased carbon dioxide levels is known as the Haldane Effect, and is important in the transport of carbon dioxide from the tissues to the lungs. Conversely, a rise in the partial pressure of CO2 or a lower pH will cause offloading of oxygen from hemoglobin. This is known as the Bohr Effect.

CO2 is carried in blood in three different ways. Most of it (about 80%–90%) is converted to bicarbonate ions HCO3− by the enzyme carbonic anhydrase in the red blood cells. 5%–10% is dissolved in the plasma and 5%–10% is bound to hemoglobin as carbamino compounds. The exact percentages vary depending whether it is arterial or venous blood.

The CO2 bound to hemoglobin does not bind to the same site as oxygen; rather it combines with the N-terminal groups on the four globin chains. However, because of allosteric effects on the hemoglobin molecule, the binding of CO2 does decrease the amount of oxygen that is bound for a given partial pressure of oxygen.