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Påverkar antihistaminer tex loratradin testo ?
https://www.researchgate.net/publication/333519232_The_potential_impact_of_1st_and_2nd_gene ration_antihistamines_on_male_fertility/link/5e7fc42192851caef4a8e743/download
"Study reports that the second-generation antihistamine cetirizine hydrochloride has potent and significant effects on male fertility compared with the first-generation H1 antihistamine pheniramine maleate through its changes in prolactin, LH, and FSH levels. These hormonal changes decreased spermatogenesis and sperm count."
"Several studies indicating that antihistamine drugs may affect testicular homeostasis by enhancing or decreasing androgen production, including several studies suggesting that daily use of the antihistamines was associated with a decrease in testosterone levels"
"The mechanism by which H1-antihistamine causes gynecomastia is explained by the structural similarity of neuroleptics and H1-antihistamines. Neuroleptic drugs block dopamine receptor in the pituitary gland, thus interrupting normal dopaminergic inhibition of prolactin secretion. In this manner, neuroleptics could increase the level of prolactin. In men, hyperprolactinemia induces hypogonadotropic hypogonadism (androgen-deficiency), and the resulting relative increases in estrogen could lead to gynecomastia."