Dödligt virus från Kina orsakar panik (SARS-CoV-2, COVID-19)

This result suggests that 2019-nCoV might mainly act on lymphocytes, especially T lymphocytes, as does SARS-CoV. Virus particles spread through the respiratory mucosa and infect other cells, induce a cytokine storm in the body, generate a series of immune responses, and cause changes in peripheral white blood cells and immune cells such as lymphocytes. Some patients progressed rapidly with ARDS (acute respiratory distress syndrome) and septic shock, which was eventually followed by multiple organ failure.

In general, the characteristics of patients who died were in line with the early warning model for predicting mortality in viral pneumonia in our previous study: the MuLBSTA score. 8 The MuLBSTA score system contains six indexes, which are multilobular infiltration, lymphopenia, bacterial coinfection, smoking history, hyper tension, and age.