Dödligt virus från Kina orsakar panik (SARS-CoV-2, COVID-19)

Mykoplasma ökar i Sverige: ”Toppen av ett isberg”
Uppdaterad 21 oktober 2024Publicerad 21 oktober 2024

Ett större utbrott av mykoplasma pågår i Sverige.

Förklaringen tros vara att immuniteten är lägre efter coronapandemin. https://www.svt.se/nyheter/inrikes/mykoplasma-okar-i-sverige-toppen-av-ett-isberg

21 okt 2024 18:28

Anna • Jag har läst studier som visar på ett skadat immunsystem efter covidinfektion. De senaste åren har ju en rad sjukdomar ökat i förekomst. Vad tänker du om det?

Det stämmer inte att immunförsvaret skadas av covidinfektion. Däremot har förekomsten av många andra infektioner varit väldigt låg under första delen av pandemin (pga vårt beteende med mindre kontakter, arbete hemma etc) vilket gjort att immuniteten i befolkningen minskat och när fler är mottagliga så ökar antalet infektioner. Så småningom kommer situationen återgå till hur den var före pandemin

Magnus Gisslén
statsepidemiolog

COVID-19 leads to long-term changes in the immune system, study shows

In a study recently published in the renowned journal "Allergy", a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. https://www.news-medical.net/news/20240715/COVID-19-leads-to-long-term-changes-in-the-immune-system-study-shows.aspx

Abstract
Background

SARS-CoV-2 has triggered a pandemic and contributes to long-lasting morbidity. Several studies have investigated immediate cellular and humoral immune responses during acute infection. However, little is known about long-term effects of COVID-19 on the immune system.

Conclusions

COVID-19 causes long-term reduction of innate and adaptive immune cells which is associated with a Th2 serum cytokine profile. This may provide an immunological mechanism for long-term sequelae after COVID-19.

(...) it thus seems that a single SARS-CoV-2 infection may cause a long-lasting impact on the cells of the innate and adaptive immune system. Since all leukocyte lineages originate from pluripotent CD34+ hematopoietic stem cells (HSC) in the bone marrow, it is tempting to speculate that such stem cells may have gotten infected by SARS-CoV-2 leading to the herein observed long-term cellular reductions. https://pubmed.ncbi.nlm.nih.gov/39003594/

One of the most concerning long-term impacts of COVID-19 is immune dysregulation and dysfunction. Immune system impacts were heavily documented, even in the first waves of the pandemic, (...) https://libguides.mskcc.org/CovidImpacts/Immune

Mykoplasma ökar i Sverige: ”Toppen av ett isberg”
Uppdaterad 21 oktober 2024Publicerad 21 oktober 2024

Ett större utbrott av mykoplasma pågår i Sverige.

Förklaringen tros vara att immuniteten är lägre efter coronapandemin. https://www.svt.se/nyheter/inrikes/mykoplasma-okar-i-sverige-toppen-av-ett-isberg

21 okt 2024 18:28

Anna • Jag har läst studier som visar på ett skadat immunsystem efter covidinfektion. De senaste åren har ju en rad sjukdomar ökat i förekomst. Vad tänker du om det?

Det stämmer inte att immunförsvaret skadas av covidinfektion. Däremot har förekomsten av många andra infektioner varit väldigt låg under första delen av pandemin (pga vårt beteende med mindre kontakter, arbete hemma etc) vilket gjort att immuniteten i befolkningen minskat och när fler är mottagliga så ökar antalet infektioner. Så småningom kommer situationen återgå till hur den var före pandemin

Magnus Gisslén
statsepidemiolog

COVID-19 leads to long-term changes in the immune system, study shows

In a study recently published in the renowned journal "Allergy", a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. https://www.news-medical.net/news/20240715/COVID-19-leads-to-long-term-changes-in-the-immune-system-study-shows.aspx

Abstract
Background

SARS-CoV-2 has triggered a pandemic and contributes to long-lasting morbidity. Several studies have investigated immediate cellular and humoral immune responses during acute infection. However, little is known about long-term effects of COVID-19 on the immune system.

Conclusions

COVID-19 causes long-term reduction of innate and adaptive immune cells which is associated with a Th2 serum cytokine profile. This may provide an immunological mechanism for long-term sequelae after COVID-19.

(...) it thus seems that a single SARS-CoV-2 infection may cause a long-lasting impact on the cells of the innate and adaptive immune system. Since all leukocyte lineages originate from pluripotent CD34+ hematopoietic stem cells (HSC) in the bone marrow, it is tempting to speculate that such stem cells may have gotten infected by SARS-CoV-2 leading to the herein observed long-term cellular reductions. https://pubmed.ncbi.nlm.nih.gov/39003594/

One of the most concerning long-term impacts of COVID-19 is immune dysregulation and dysfunction. Immune system impacts were heavily documented, even in the first waves of the pandemic, (...) https://libguides.mskcc.org/CovidImpacts/Immune

Citat:Ursprungligen postat av Lamento
Det dör 5-10 personer av Covid-19 fortfarande varje vecka i Sverige.

-Vad tycker du att man skall göra åt det då?

‘Unusual’ cancers emerged after the pandemic. Doctors ask if covid is to blame.


(...) It was 2021, a year into the coronavirus pandemic, and as he slid into a chair, Patel shared that he’d just seen a patient in his 40s with cholangiocarcinoma, a rare and lethal cancer of the bile ducts that typically strikes people in their 70s and 80s. Initially, there was silence, and then one colleague after another said they’d recently treated patients who had similar diagnoses. Within a year of that meeting, the office had recorded seven such cases.

“I’ve been in practice 23 years and have never seen anything like this,” https://www.washingtonpost.com/health/2024/06/06/covid-cancer-increase-link/

Conclusions: Pre-existing CCCoV Abs do not interfere with the development of vaccine-induced immunity. However, vaccine-associated Abs wane over time, which may be associated with the increasing IgG4 Ab response.https://www.mdpi.com/2076-393X/13/5/547

In our HCW cohort, SARS-CoV-2 S protein-specific IgG4 Ab levels increased significantly by the end of the study period, which is consistent with previous findings for COVID-19 mRNA vaccines [2,61,62]. While human IgG1 and IgG3 Abs are mostly associated with antiviral/protective immune responses, IgG4 Abs are known to be associated with poor Fc functional activity, decreased IgG1 and IgG3 levels, and a shift toward a tolerogenic immune response [2,61]. Consistent with our data, IgG4 class switch and decreased Fc functional capacity were observed following mRNA (mRNA-1273/BNT162b2) but not recombinant protein-based (Novavax) vaccination against SARS-CoV-2 in adults and children [39,62,63,64,65,66,67]. Additionally, this study further corroborates our data demonstrating higher IgG4 levels in those receiving the mRNA-1273 vs. BNT162b2 vaccine (Figure 9B). IgG4-biased immune response results from antigen persistence, increased antigen doses, or repeated exposure to viral components, and most evidence shows that it is not associated with improved viral clearance, in contrast to IgG1 and IgG3 [37,65]. So, it is consistent that the mRNA-1273 vaccine delivering 100 µg of mRNA/dose (vs. 30 µg/dose of the BNT162b2 vaccine) ultimately led to significantly higher IgG4 Ab levels. Thus, while the induction of IgG4 may offer benefits in terms of reducing inflammation and enhancing tolerance, it also raises questions about the potential interference with antigenic clearance and the long-term vaccine efficacy.