Additionally, recent investigations have found abnormally high levels of IgG4 in people who were administered two or more injections of the mRNA vaccines. (...) However, emerging evidence suggests that the reported increase in IgG4 levels detected after repeated vaccination with the mRNA vaccines may not be a protective mechanism; rather, it constitutes an immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses. Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals. https://www.mdpi.com/2076-393X/11/5/991Vi kan ta Kiszel et al, 13 aug 2023 i tidskriften Nature. Artikeln är "Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history". Jag citerar:
high levels of IgG4 expression can appear after allergen-specific immunotherapy43 or in several types of cancers44, which is beneficial in allergic diseases but may indicate impaired humoral immunity to tumors. https://www.nature.com/articles/s41598-023-40103-xVi kan ta Akhtar et al 20 dec 2023 i Frontiers in Immunology, "Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations":
IgG4 responses exhibited a distinct pattern. IgG4 remained undetectable initially but increased extensively six months after the second mRNA dose, eventually replacing IgG1 after the 3rd/4th mRNA doses. (...) The role of the least abundant IgG4 is not well understood in terms of its regulatory functions in various diseases. Depending on the type and condition of the disease, this regulatory role can be either beneficial or detrimental (11). IgG4 shows an advantageous effect in response to allergen and parasitic infection allergen and parasitic response while countering hypersensitivity (22–24), yet contributing to the onset and progression of autoimmune diseases, tumor immunology, and IgG4-related diseases, lacking specific treatments (11). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763240/Det finns fler, men jag tar Espino et al 26 jan 2024, i tunga tidskriften Viruses, med "The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer–BioNTech Vaccine":
IgG4 is typically induced during helminth infections and allergic diseases where this antibody subclass plays a protective role [61]. However, in other circumstances, a high level of IgG4 in the serum is considered pathogenic because it could trigger an autoimmune disease [68], cancer [69,70], or many other illnesses such as lymphadenopathy [71], interstitial pneumonitis [72], and aortic aneurism [73]. Hence, it has been proposed that instead of being beneficial, repeated vaccinations tend to induce immunological tolerance. This could occur because the amount of spike protein produced in response to repeated mRNA administration is too high and lasts too long in the body. The continuous exposure of T-cells to such a large amount of spike protein could desensitize the CD4+ and CD8+ cells, making them lose their capacity to proliferate and, consequently, lose their capacity to respond appropriately to re-infections with SARS-CoV-2 variants [74]. If this happens, the immune system could become exhausted, leading to autoimmunity [74]. Therefore, it is not unlikely that subjects who have received booster injections and who are re-exposed to the virus may suffer a more severe COVID-19 disease. https://www.mdpi.com/1999-4915/16/2/187Så att mRNA-vaccinet ger konstigt förhöjda IgG4 är väl belagt i många fler studier än dessa. Att förhöjt IgG4 kopplas till cancer vet man också, och du ser det till exempel i studierna ovan. Frågan gäller nu om antikroppen som de flesta som har tagit till exempel Pfizers mRNA-vaccin försvårar kroppens försvar mot cancer eller inte.
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