Varför har CELSIUS tagit bort koffeinhalten?

Caffeine’s effects will last for several hours, depending on how quickly or slowly it is metabolised by the body.
The clearance of caffeine and may be affected by factors such as gender, race, genetic polymorphisms, disease, and exposure to inducers.
Two studies have reported that regular intakes of caffeine for one week did not alter caffeine pharmacokinetics. However, a further study suggested that the daily consumption of at least 3 cups of coffee increased CYP1A2 activity.
1. Cirrhosis and hepatitis B or C, suggesting that they may cause a reduction of plasma clearance.
2. Smoking (nicotine) stimulates caffeine clearance, and almost doubles the rate of caffeine metabolism as a result of enzyme induction.
3. Grapefruit juice consumption decreases caffeine clearance by 23% and prolongs half-life by 31%.
4. Caffeine metabolism is reduced, particularly during the third trimeste.
5. Alcohol intake of 50g per day prolongs caffeine half-life by 72% and decreases caffeine clearance by 36%20.
6. Genetic variability in caffeine receptors ADORA2A polymorphism.
The distribution of distinct genotypes of the adenosine A2A receptor gene (ADORA2A) differs between self-rated caffeine-sensitive individuals with reduced sleep quality, and caffeine-insensitive individuals40.
7. A polymorphism of the gene coding for CYP1A2, the enzyme responsible for 95% of caffeine metabolism, may potentially divide the population into ‘slow’ and ‘fast’ [and ultrafast] caffeine metabolisers.
Age, gender and ethnicity. The same amount of caffeine can therefore affect two otherwise similar individuals differently, depending on their genetic make-up.