En rapport som argumenterar för att använda melatonin förebyggande mot covid19. Ökar effekten av vaccinerna dessutom. Har själv tagit melatonin under pandemin...
(1)
Melatonin is a simple molecule, with well-documented pathophysiological functions, such as: the anti-inflammatory, antioxidant, and immunomodulatory action, as well as its inhibitory capacity of the Mpro protease and the MMP9 protein, which would make it a therapeutic alternative to consider against various infectious diseases.
(2)
It has been known for years and it has been demonstrated once again with the administration of vaccines that the administration of melatonin can enhance the immune response, with a response in the rate of specific antibodies much higher than when the vaccine components are administered without melatonin.
(3)
Before the onset of this pandemic, it had been shown in various viral infections that it could inhibit and/or mitigate the pathogenic action of these microbial agents in experimental animals.
(4)
When melatonin is used in the laboratory (animal experimentation) and in the human clinic, a very wide safety margin has been demonstrated, well above most of the drugs used in ICUs against SARS-CoV-2 infection.
(5)
We believe that there is a sufficient level of scientific evidence to authorize its use as a preventive drug against COVID-19 infection, due to its proven physiological actions, although it must be said that the exact dose to achieve this preventive effect has still not been determined.
(6)
In infected patients with progressive disease, the scientific evidence is clear, and its administration is recommended for several reasons: (a) because it has been able to significantly reduce the consequences of the disease; (b) because there are no studies that say otherwise; (c) because its security profile is very broad.
(7)
Although several administration guidelines have already been published in patients infected with SARS-CoV-2, it would be advisable to launch new clinical trials to define the best administration protocol, especially regarding dose and times when it should be administered, to respect its circadian rhythmicity.
https://www.mdpi.com/1467-3045/44/1/3/htm
