Dödligt virus från Kina orsakar panik (SARS-CoV-2, COVID-19)

Jönköpings kommun planerar att stänga bland annat parkeringar och parker på grund av risk för spridning av covid-19.

In the upcoming manuscript I will share my insights on the immune pathogenesis of Coronavirus pandemics. Those are based on an in-depth analysis of Covid-19-relevant scientific literature (key references will be appended) and backed by my deep vaccine knowledge and relentless perseverance in unraveling the host’s immune defense mechanisms and strategies viruses have evolved to escape those. Understanding the interplay between the virus and the host immune system is a prerequisite for designing vaccines able to counter the immune subversive strategy of infectious pathogens. I do not think that it is reasonable for WHO or any other health authority to approve ‘emergency use’ of vaccines aimed at conducting mass vaccination campaigns in the very heat of an infectious pandemic without having gained an in-depth understanding of how this may impact on the outcome of the pandemic.

In particular, lack of understanding of the consequences of immune pressure on highly mutable viruses has now allowed for the approval of a number of Covid-19 vaccines that are completely contraindicated for fighting a pandemic, regardless of the technology used. Although safe and efficacious and providing temporary relief to part of the population and to healthcare facilities, these vaccines will soon come with a heavy toll to be paid by the entire population if mass vaccination campaigns continue.

Again, given the urgency of my call, I will neither allow time for peer-review, nor for English proofreading, nor for fine-tuning the wording or for screening the manuscript for redundancy. As I merely seek to provide enough of compelling scientific proof for sounding this warning bell, I will not deal with relevant matters as exhaustively as I would normally do. Clearly, the upcoming manuscript is not meant to be submitted to a scientific peer-reviewed journal but to explain the scientific rationale behind my cry of distress and urgent wake-up call. May they for God’s sake draw the world’s attention to what I think is now likely to become the biggest and most tragic mistake made in the history of public health in general and in the field of vaccination in particular.

Nevertheless, you may still opt for now to not believe the statements, conclusions and forecasts that will be made in this manuscript and which have already been summarized as attached. However, I have no doubt that in the days and weeks to come ‘doubting Thomas’ will have to admit that he was proven wrong. In the meantime, these disastrous vaccination campaigns will likely be intensified and even extended to younger age groups. Given the power, influence and blind ambition of the stakeholders driving these campaigns, it is going to be incredibly difficult to stop this act of complete madness. When all of them will finally have to admit the catastrophic consequences of this ‘experiment’, precious time and, more importantly, many more lives will have been lost. Eventually, complete lockdowns will likely be imposed for an undefinite period of time as a last resort.

But mass vaccination campaigns will also have severe consequences for those who got vaccinated first (mostly the elderly or people with underlying disease or those who are otherwise immunocompromised). In the highly likely event that mass vaccination will soon result in antiviral resistance (see below), these people will have no single bit of immunity left to rely upon. In contrast to the infectious circulating virus, current vaccines do either not contain any critical killer cell motif or fail to activate dedicated killer cells. It goes, therefore, without saying that vaccine-induced immune responses will inevitably result in a dramatic enhancement of morbidity and mortality rates in all of the human population (except for small children?).

Further to all of the above, low exposure to circulating CoV strains (e.g., due to stringent containment measures) will increasingly weaken innate mucosal immunity for lack of training. Again, this is particularly relevant for those who – thanks to their sufficient and adequate innate immune defense – got away with asymptomatic infection during the first wave. Stringent and widespread infection prevention measures are now increasingly compromising their innate immunity and rendering them more susceptible to symptomatic infection. Especially the younger age groups may, therefore, end up with relatively higher morbidity and mortality rates, even regardless of the emergence of more infectious viral variants. This is to say that broadly implemented infection prevention measures will only amplify the already detrimental consequences of ongoing mass vaccination campaigns. It is reasonable to assume that the combination of non-selective and selective immune escape will cause morbidity and mortality rates in younger age groups to explode.

The more Covid-19 vaccination campaigns in the young and middle-age groups will be delayed (i.e., relative to their initiation in the elderly), the more they will enhance morbidity and mortality rates in this group: By the time mass vaccination campaigns are about to start in the young and middle-aged groups, a substantial number of these people will already have been infected with Covid-19. Enhanced rates of infection by highly infectiousness viral variants significantly has now increased the likelihood for them to become re-infected while being in the process of seroconverting. So, by the time vaccinations will be initiated, viral immune escape in this group may already be fueling a vicious circle of enhanced viral infectiousness resulting in more seroconversion and hence, more immune escape. Mass vaccination campaigns in this group will only dramatically deteriorate the situation as they will lead to a fast and massive increase in the number of asymptomatic subjects that are in the process of seroconverting against a highly infectious background. and, therefore, prone to promoting viral immune escape. As there is naturally no reason for them to isolate, there will be plenty of opportunity for the highly infectious circulating strains to replicate in the presence of suboptimal Ab titers and, therefore, to escape the host’s immune control.

As large scale vaccination campaigns combined with the sustained implementation of several containment measures will only expedite the occurrence of viral escape mutations, the illusory hope that current Covid-19 vaccines could generate herd immunity should once and for all be thrown overboard. Along the same line of reasoning, it is not unthinkable that Covid-19 will, once again, cross species barriers. One can definitely not rule out that with growing immune- mediated selection of virus variants, Covid-19 is ultimately going to be able to jump to other animal species, especially industrial livestock (e.g., intensive pig and poultry farms with high stocking density) as i) these species are already known to host several different Coronaviruses and ii) variability/ mutations in the very same spike protein, and particularly in the RBD, are known to be responsible for shifts in host tropism/ susceptibility. Similar to the situation with influenza virus, these animal species could then constitute a reservoir for SARS-COVID-2 virus. Depending on the prevalence of circulating animal CoVs in those farms (and hence, the level of trained immunity), those animals could now serve as asymptomatic carriers, thereby constituting a serious threat to humans.

Conclusion

The combination of mass vaccination and infection prevention measures is a recipe for a global health disaster. Following the science, one has to conclude that all age groups (possibly with the exception of small children) will be heavily affected and subject to rates of morbidity and mortality that raise much faster and much higher than those expected to occur during the natural course of a CoV pandemic. This will particularly apply if the sequence of mass vaccinations following the first infectious wave parallels that of natural infection (i.e., immunocompromised people and elderly first, followed by the younger age groups).

No one, for that matter, should be granted a right to implement large-scale pharmaceutic and non-pharmaceutic immune interventions, especially not during a viral pandemic, and certainly not without an in-depth understanding of the immune pathogenesis of a viral pandemic. When one follows the science, and nothing but the science, it becomes extremely difficult to not label ongoing mass vaccination campaigns as a crime, not only to public health but also to individual health.