Citat:
Ursprungligen postat av
crisscross
Ja, kolesterol har en roll för alla virus som angriper luftvägarna tex. influensa. Så visst kan det vara en delförklaring till stora skillnader mellan riskgrupper och övriga.
Kolesterol ökar med åldern
https://www.medicalnewstoday.com/articles/315900
Taken together our findings show the level of cellular cholesterol is a core contributor to SARS-CoV-2 viral entry. During inflammation cellular cholesterol is further increased by cytokines10. This suggest a unique effect where cholesterol concomitantly increases both inflammation and the efficiency of viral entry. Almost all respiratory viruses induce inflammation, but our mechanism suggests SARS-CoV-2 is particularly sensitive due to the increased entry in high cholesterol.
Based on the finding of ACE2 sensitivity to cholesterol and PIP2 and increased cholesterol with age and disease, we propose a model for age dependent infection of SARS-CoV-2 (Figure 3F). When cholesterol is low there are very few entry points (similar to children). With age, average cellular cholesterol levels in the lung increases, thereby increasing the number and size of viral entry points (similar to adults). In chronically ill patients, cellular cholesterol levels increase dramatically and all the ACE2 receptor is positioned for viral infectivity (adults + chronic inflammation). The model is supported by age dependent loading of cholesterol into lung tissue of mice Figure 3A–B and the simultaneous translocation of ACE2 from PIP2 domains to GM1 rafts (Figure 2C)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263494/
