Citat:
Ursprungligen postat av
Pisseman
Som jag förstått det så har man i Danmark hittat 501Y-mutationen, men man vet inte om det är den engelska varianten än. Någon som har bättre koll på detta än vad jag har?
501Y har ju hittats på flera håll i världen (oberoende av varandra). Den engelska varianten har dock flera andra mutationer också.
Ja den ingår i dem aminosyror viruset använder för att binda till ACE2 receptor. Vi måste lyssnar på medcram, hoppas han kommer ut med info om detta snarast. Det är tydligen det dem är rädda för, att detta ska göra att spikeproteinet ändrar sig så vaccinet inte / får svårt att känna igen proteinet på spiken?
Citat:
The lineage B.1.1.71 is of particular interest (see footnote) and is notable for a higher number of mutations
in one lineage than observed previously (Table 1b). It has been speculated that it may have arisen from a
chronically infected individual. One of these (the N501Y mutation) occurs in the region of the Spike protein,
the receptor binding domain (RBD), that the virus uses to bind to the human ACE2 receptor. Changes in
this region of the Spike protein can result in the virus changing its ACE2 binding specificity and alter
antibody recognition.
Ser inte att samma finns / fanns i Danmark. Iallafall inte i rapporten från igår.
Citat:
Y453F was identified in the Netherlands and Denmark associated with mink-human infections and in
particular in Danish cluster 5 which was defined as a cluster of variants carrying four mutations, the 69-
70del and three amino acid replacements (Y453F, I692V and M1229I) in the Spike protein, and spreading
among farmed mink and a small number of people in Denmark (Table 1b). This lineage raised concerns
because of a reported reduction of neutralization activity of sera from people recovered from infection,
but further studies are required. The Y453F mutation, which occurs in the RBM, although rare, has also
been observed previously in SARS-CoV-2 genomes isolated from humans, but never in the UK. This
mutation has arisen independently multiple times in several countries. Y453F has also been shown in
laboratory studies to increase the affinity of Spike protein binding to the hACE2 receptor.
https://www.cogconsortium.uk/wp-content/uploads/2020/12/Report-1_COG-UK_20-December-2020_SARS-CoV-2-Mutations_final.pdf
