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Ursprungligen postat av
Pisseman
Eller för att förtydliga lite, Lipiderna som omsluter mRNA är känsliga. Modernas Lipider är stabilare än Pfizers diton.
Så tolkar inte jag den begränsade information som finns ute om detta. M och P-vaccinen har olika lipid-nano-partiklar men i grunden handlar det om att inte mRNA:t skall förstöras.
Moderna verkar ha lite mer erfarenhet av mRNA vaccin så de kanske vågar sätta en högre temperatur helt enkelt. Eller så har de mer våghalsiga affärsjurister, Moderna är ju uppstickare dessutom.
"Because the specific formulations are secret, Liu says, it's not clear exactly why these two mRNA vaccines have different temperature requirements.
"It just comes down to what their data is," she says of Moderna's vaccine. "If their data shows that it's more stable at a certain temperature, that's it.""
"Moderna spokesperson Colleen Hussey explained to NPR in an email that its vaccine doesn't need to be kept so cold because of its particular "lipid nanoparticle properties and structure," and because the company has learned from experience — it's developed ten mRNA vaccine candidates already. "Now we don't need [ultra-cold conditions] as the quality of product has improved and [it] doesn't need to be highly frozen to avoid mRNA degradation," Hussey explained."
https://www.npr.org/sections/health-shots/2020/11/17/935563377/why-does-pfizers-covid-19-vaccine-need-to-be-kept-colder-than-antarctica?t=1607113585520