Svensk studie. Var det efter denna FHM skiftade fokus från de dödliga antikropparna till T-cellsimmunitet?
https://www.medrxiv.org/content/10.1101/2020.07.17.20155937v1
Disease-associated antibody phenotypes and probabilistic seroprevalence estimates during the emergence of SARS-CoV-2. Elevated anti−SARS−CoV−2 antibody levels were associated with hospitalization, with IgA titers, increased circulating IL−6 and strong neutralizing responses indicative of intensive care status.
För de som inte vet vad antikroppar kan ställa till med:
https://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
https://www.medrxiv.org/content/10.1101/2020.07.16.20154088v1
Hur länge ska FHM köra med T-cellsimmunitet den här gången?
https://www.medrxiv.org/content/10.1101/2020.05.13.20100636v1
Although the higher magnitude and superior functionality of SARS-CoV-2-reactive T-cells in critical patients can also be a result of a stronger immunogenicity provided by severe infection, it disproves the hypothesis of insufficient SARS-CoV-2-reactive immunity in critical COVID-19.
To this end, activation of effector T-cells with differentiated memory phenotype found in our study could cause hyper-reactive response in critical cases leading to immunopathogenesis.