Citat:
Du länkar en studie på 20 personer som varit sjuka i COVID-19, med bekräftad sjukdom.https://www.nature.com/articles/s41392-020-00228-1
Substantial TD4+ response in recovered patients correlated to heightened IgG and IgA production in serum/mucosa tract only points further to antibodies being the neutralizing force, guided by TD4+ cells which cannot alone defeat the virus without B-Cells. TD8+ cells did not generate in all cases of the defeated infection, mirroring my doubts on adaptive immunity.
Also brought up are the exact doubts I expressed regarding the theory:
In short, expressing the need to define the length of time T-Cells and antibodies survive in serum comparatively to be able to make any claim on cross-reactivity within a population (TD4+ in 100% of recovered cases meaning larger IgA titers for instance, which are the most neutralizing and short-lived in serum).
Secondly, it’s important to remember that cross-reactive T-Cell’s from human cold coronaviruses appear to be a lot weaker than T-Cells differentiated by a SARS-COV-2 response and even weaker than those differentiated by a vaccine response. Because human cold antibodies are not neutralizing antibodies.
So, again. No adaptive immunity. No TD8+ cytotoxic cell response in 100% of recovered patients to confirm this, but 100% of recovered patients show a TD4+ response, which correlates to IgA and IgG antibody production. No evidence of T-Cell cross-reactive immunity being a thing. No evidence that cross-reactive T-cells even change a potential outcome yet. No evidence that previous research hasn’t just measured both uninfected patients with non-neutralizing T-cell cross-reactivity, or non-measurable antibody serum levels after four months while T-cells persist.
Remember this when the FHM use the T-cell study to support their claims of herd immunity being reached (I heard they did this just this week). Remember that’s bullshit. Remember this when people tell you there is a large inherent immunity in a population. Remember that’s bullshit.
Substantial TD4+ response in recovered patients correlated to heightened IgG and IgA production in serum/mucosa tract only points further to antibodies being the neutralizing force, guided by TD4+ cells which cannot alone defeat the virus without B-Cells. TD8+ cells did not generate in all cases of the defeated infection, mirroring my doubts on adaptive immunity.
Also brought up are the exact doubts I expressed regarding the theory:
However, further studies are required on samples from acute patients and patients with complicated disease courses which will tell us the T cell responses for the whole duration of the disease. In addition, the common cold history and matched blood samples were not fully detailed for each patient. These data could provide us with more conclusions regarding the abundance of crossreactive coronavirus T cells before exposure to SARS-CoV-2. Moreover, further studies on the longevity of the SARS-CoV-2 immunological memory have to be conducted on samples from recovered patients.
In short, expressing the need to define the length of time T-Cells and antibodies survive in serum comparatively to be able to make any claim on cross-reactivity within a population (TD4+ in 100% of recovered cases meaning larger IgA titers for instance, which are the most neutralizing and short-lived in serum).
Secondly, it’s important to remember that cross-reactive T-Cell’s from human cold coronaviruses appear to be a lot weaker than T-Cells differentiated by a SARS-COV-2 response and even weaker than those differentiated by a vaccine response. Because human cold antibodies are not neutralizing antibodies.
So, again. No adaptive immunity. No TD8+ cytotoxic cell response in 100% of recovered patients to confirm this, but 100% of recovered patients show a TD4+ response, which correlates to IgA and IgG antibody production. No evidence of T-Cell cross-reactive immunity being a thing. No evidence that cross-reactive T-cells even change a potential outcome yet. No evidence that previous research hasn’t just measured both uninfected patients with non-neutralizing T-cell cross-reactivity, or non-measurable antibody serum levels after four months while T-cells persist.
Remember this when the FHM use the T-cell study to support their claims of herd immunity being reached (I heard they did this just this week). Remember that’s bullshit. Remember this when people tell you there is a large inherent immunity in a population. Remember that’s bullshit.
KI:s studie var på personer som utsatts för viruset, men inte utvecklat sjukdom. Det var därför den var intressant.