Citat:
Även KI såg ju T-celler i blod från 2019. Men den kopplingen försvann när de bara kollade personer som hade T-celler mot både Nucleus + Spike or Membrane.
Yes, that would speak against the theory. But it has been witnessed in other T-Cell reports:
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity
“The teams also asked whether people who haven’t been infected with SARS-CoV-2 also produce cells that combat it. Thiel and colleagues analyzed blood from 68 uninfected people and found that 34% hosted helper T cells that recognized SARS-CoV-2. The La Jolla team detected this crossreactivity in about half of stored blood samples collected between 2015 and 2018, well before the current pandemic began. The researchers think these cells were likely triggered by past infection with one of the four human coronaviruses that cause colds; proteins in these viruses resemble those of SARS-CoV-2.”
Nonetheless, I don’t see how this isn’t promoting somewhere around a 1.1 ratio in recent cases, with antibodies waning over time to reveal more of these cases, considering how the prevalence (in comparison) seems to rise alongside time since infected. In the most recent cases the ratio is nowhere near two, sadly, and I think should be the most telling find of this paper. Which also makes sense with closed population studies where there has been 90+% infections that seroconvert, or towns with huge amounts of spread that have seroconverted.
But at the same time, I was hoping this paper would answer questions and not bring up more. It’s entirely possible that I’m completely wrong and these help mitigate a second infection in people with strong immune systems. It’s entirely possible this is mostly a case of waning antibodies. It’s entirely possible these are just cross-reactive T-Cells that possibly grant immunity or possibly don’t do very much. It’s entirely possible this is just a response to dead viral fragments and these T-Cell responses are in patients who have never been infected.
It’s very confusing, man. I wonder what the peer review will bring.
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity
“The teams also asked whether people who haven’t been infected with SARS-CoV-2 also produce cells that combat it. Thiel and colleagues analyzed blood from 68 uninfected people and found that 34% hosted helper T cells that recognized SARS-CoV-2. The La Jolla team detected this crossreactivity in about half of stored blood samples collected between 2015 and 2018, well before the current pandemic began. The researchers think these cells were likely triggered by past infection with one of the four human coronaviruses that cause colds; proteins in these viruses resemble those of SARS-CoV-2.”
Nonetheless, I don’t see how this isn’t promoting somewhere around a 1.1 ratio in recent cases, with antibodies waning over time to reveal more of these cases, considering how the prevalence (in comparison) seems to rise alongside time since infected. In the most recent cases the ratio is nowhere near two, sadly, and I think should be the most telling find of this paper. Which also makes sense with closed population studies where there has been 90+% infections that seroconvert, or towns with huge amounts of spread that have seroconverted.
But at the same time, I was hoping this paper would answer questions and not bring up more. It’s entirely possible that I’m completely wrong and these help mitigate a second infection in people with strong immune systems. It’s entirely possible this is mostly a case of waning antibodies. It’s entirely possible these are just cross-reactive T-Cells that possibly grant immunity or possibly don’t do very much. It’s entirely possible this is just a response to dead viral fragments and these T-Cell responses are in patients who have never been infected.
It’s very confusing, man. I wonder what the peer review will bring.
