Citat:
Ursprungligen postat av
Merwinna
Hela min omgivning är däckad i vinterkräksjukan nu, jag klarar mig som vanligt tack vare min genetiska immunitet.
Tyvärr finns det ju norovirusvarianter som den genetiska immuniteten, FUT2 mutation rs601338 (A;A), inte skyddar mot, individer med mutationen i FUT2, så kallade non-secretors, kan exempelvis infekteras av norovirus genotype GII.2 samt genotype GI.3:
Citat:
Non-secretors are, however, susceptible to other norovirus strains. A challenge study using the Snow Mountain strain (genotype GII.2) showed no association between secretor status or ABH group antigens and susceptibility [21]. Two observational studies, one of a waterborne and another of a foodborne outbreak caused by genotype GI.3 strains in the Netherlands and Sweden, respectively [22,23], found no association between secretor status and susceptibility to symptomatic infection. Moreover, a birth cohort study in Ecuador with prospective follow-up found significantly higher rates of non-GII.4 norovirus infections in secretor-negative children [15], suggesting that the non-secretor geno/phenotype may increase susceptibility to certain norovirus genotypes.
Overall, several in vivo studies in various settings and countries have, with a few exceptions, consistently shown strong protection of non-secretors against GII.4 infections. However, non-secretors are susceptible to a wide array of other norovirus genotypes, the clinical and epidemiological significance of which is less well studied. No in vivo study has demonstrated specific norovirus genotypes that exclusively infect non-secretors, but rather genotypes that are secretor-independent.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005385
Individer med mutationen i FUT2 är dock skyddade mot den mest dominerande och under vintersäsongen vanligast förekommande virusvarianten GII.4.
Finns även andra genvarianter i genen FUT2 som gör att en individ är FUT2 non-secretor som exempelvis rs1047781 genotype (T;T).
