10år AAS, första gången DNP-logg

Avery interestingphenomenon is observedwith the change of seasons. As summer passes into fall, it is found that thepatient suddenly ceases to loseweight, although the weight loss beforemay have been very satisfactoryandsteady. That themechanisminvolved is not the development of tolerance is attested by the fact that a considerable group of patients exhibit this phenomenon simultaneously. In the case of dinitro¬ phenol itmay bepartlyaccounted for, but onlypartly, by the diminution of sweating that accompanies the colderweather. Inthehot summermonths, small doses of dinitrophenolwill produce aweight loss thatwill be matched inthecoldwintermonthsonlybyconsiderably larger doses. Such loss of the calorigenic power of certaindrugs at lowtemperatures has been known for some time.37 Theprovedcapacityof lowtemperatures toabolishandevenreversethecalorigenicactionof cer¬ tain substances (endogenous and exogenous in type) hasnoadequateexplanation.