Citat:
Du kan väldigt lätt kolla upp att aluminium blockar elektriska signaler
Jämförde du precis aluminium som blockar signaler och en magnet ? 😅
In general, neurotoxins block in one way or another the transmission of the nerve impulse. A variety of animal neurotoxins act postsynaptically. They bind the acetylcholine receptor, the acetylcholinesterase or ion channels thereby blocking or altering their function. The majority of neurotoxins act presynaptically by binding specifically to ion channels, and the ensuing strong alteration of the permeability of the neuronal plasma membrane to selected ions results in an indirect inhibition of neuroexocytosis and in the blockade of the transmission of nerve signals. Neurotoxins that act simply by binding to neuronal molecules, thereby altering their physiological activity, are not dealt with in the present review, which focuses on the structure and mechanism of action of three groups of presysnaptic neurotoxins that interfere directly and specifically with neurotransmitter release. Previous reviews have analyzed structural and functional aspects of these neurotoxins (149,245, 419, 440, 509,527, 620) as well as electrophysiological, ultrastructural, and molecular aspects of neuroexocytosis (48, 125, 590,620). This review aims to provide an analysis of the mode of action of neurotoxins directly altering neuroexocytosis, in relation to the recent knowledge acquired on the synaptic vesicle exocytosis and endocytosis cycle.
https://journals.physiology.org/doi/full/10.1152/physrev.2000.80.2.717
Jämförde du precis aluminium som blockar signaler och en magnet ? 😅
In general, neurotoxins block in one way or another the transmission of the nerve impulse. A variety of animal neurotoxins act postsynaptically. They bind the acetylcholine receptor, the acetylcholinesterase or ion channels thereby blocking or altering their function. The majority of neurotoxins act presynaptically by binding specifically to ion channels, and the ensuing strong alteration of the permeability of the neuronal plasma membrane to selected ions results in an indirect inhibition of neuroexocytosis and in the blockade of the transmission of nerve signals. Neurotoxins that act simply by binding to neuronal molecules, thereby altering their physiological activity, are not dealt with in the present review, which focuses on the structure and mechanism of action of three groups of presysnaptic neurotoxins that interfere directly and specifically with neurotransmitter release. Previous reviews have analyzed structural and functional aspects of these neurotoxins (149,245, 419, 440, 509,527, 620) as well as electrophysiological, ultrastructural, and molecular aspects of neuroexocytosis (48, 125, 590,620). This review aims to provide an analysis of the mode of action of neurotoxins directly altering neuroexocytosis, in relation to the recent knowledge acquired on the synaptic vesicle exocytosis and endocytosis cycle.
https://journals.physiology.org/doi/full/10.1152/physrev.2000.80.2.717
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