Dödligt virus från Kina orsakar panik (SARS-CoV-2, COVID-19)

Det är ett jäkla grinande.
Jag säger det som Greta egentligen står för:
Världen skulle må bra av att 2-3 miljarder människor dog.
Corona e en jäkla parantes.
Jordens befolkning ökar fortfarande som en jäkla motherfucker.

Sant men detta virus är för tamt för att kunna ta död på så många .

Gick ner lite på IVA under helgen (375) men nu verkar det öka igen (385).

https://portal.icuregswe.org/siri/report/corona.covid-dagligen

81% av alla invånare 60+ år i Region Jönköping har nu fått minst 1 vaccindos. Regionen inleder nu vaccinering av riskgrupper i åldern 18-59 år, två veckor före plan.

Det syns också en tydlig nedgång i nya fall, något som även börjat visa sig på sjukhustrycket. Det är dock fortfarande en hög nivå på såväl nya fall som inlagda.



https://rjl.se/nyheter/nyheter-och-pressmeddelanden/presstraff-26-april-2021-85931

Det har aldrig gått ner under helgen.
Det är bara ryckighet i rapporteringen.
Trenden är dock sjuknande överlag.

Det finns inget vetenskapligt stöd för att munskydd skyddar mot virus, men gott om stöd för att det inte gör det. Vi kör en repris på den här länksamlingen angående munskydd:

https://jamesfetzer.org/2020/08/studies-of-surgical-masks-efficacy-masks-are-useless-in-preventing-the-spread-of-disease/
https://journals.sagepub.com/doi/pdf/10.1177/0310057X0102900402
J Xiao, E Shiu, et al. Nonpharmaceutical measures for pandemic influenza in non-healthcare settings – personal protective and environmental measures. Centers for Disease Control. 26(5); 2020 May.
https://wwwnc.cdc.gov/eid/article/26/5/19-0994_article
J Brainard, N Jones, et al. Facemasks and similar barriers to prevent respiratory illness such as COVID19: A rapid systematic review. MedRxiv. 2020 Apr 1.
https://www.medrxiv.org/content/10.1101/2020.04.01.20049528v1.full.pdf
L Radonovich M Simberkoff, et al. N95 respirators vs medical masks for preventing influenza among health care personnel: a randomized clinic trial. JAMA. 2019 Sep 3. 322(9): 824-833.
https://jamanetwork.com/journals/jama/fullarticle/2749214
J Smith, C MacDougall. CMAJ. 2016 May 17. 188(8); 567-574.
https://www.cmaj.ca/content/188/8/567
F bin-Reza, V Lopez, et al. The use of masks and respirators to prevent transmission of influenza: a systematic review of the scientific evidence. 2012 Jul; 6(4): 257-267.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779801/
J Jacobs, S Ohde, et al. Use of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: a randomized controlled trial. Am J Infect Control. 2009 Jun; 37(5): 417-419.
https://pubmed.ncbi.nlm.nih.gov/19216002/
M Viola, B Peterson, et al. Face coverings, aerosol dispersion and mitigation of virus transmission risk.
https://arxiv.org/ftp/arxiv/papers/2005/2005.10720.pdf
S Grinshpun, H Haruta, et al. Performance of an N95 filtering facepiece particular respirator and a surgical mask during human breathing: two pathways for particle penetration. J Occup Env Hygiene. 2009; 6(10):593-603.
https://www.tandfonline.com/doi/pdf/10.1080/15459620903120086
F Blachere, W Lindsley et al. Assessment of influenza virus exposure and recovery from contaminated surgical masks and N95 respirators. J Viro Methods. 2018 Oct; 260:98-106.
https://pubmed.ncbi.nlm.nih.gov/30029810/
F Blachere, W Lindsley et al. Assessment of influenza virus exposure and recovery from contaminated surgical masks and N95 respirators. J Viro Methods. 2018 Oct; 260:98-106.
https://pubmed.ncbi.nlm.nih.gov/30029810/
A Chughtai, S Stelzer-Braid, et al. Contamination by respiratory viruses on our surface of medical masks used by hospital healthcare workers. BMC Infect Dis. 2019 Jun 3; 19(1): 91.
https://pubmed.ncbi.nlm.nih.gov/31159777/
L Zhiqing, C Yongyun, et al. J Orthop Translat. 2018 Jun 27; 14:57-62.
https://pubmed.ncbi.nlm.nih.gov/30035033/
C MacIntyre, H Seale, et al. A cluster randomized trial of cloth masks compared with medical masks in healthcare workers. BMJ Open. 2015; 5(4)
https://bmjopen.bmj.com/content/5/4/e006577
A Beder, U Buyukkocak, et al. Preliminary report on surgical mask induced deoxygenation during major surgery. Neurocirugia. 2008; 19: 121-126.
http://scielo.isciii.es/pdf/neuro/v19n2/3.pdf
D Lukashev, B Klebanov, et al. Cutting edge: Hypoxia-inducible factor 1-alpha and its activation-inducible short isoform negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol. 2006 Oct 15; 177(8) 4962-4965.
https://www.jimmunol.org/content/177/8/4962
A Sant, A McMichael. Revealing the role of CD4+ T-cells in viral immunity. J Exper Med. 2012 Jun 30; 209(8):1391-1395.
https://europepmc.org/article/PMC/3420330
T Jefferson, M Jones, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. MedRxiv. 2020 Apr 7.
https://www.medrxiv.org/content/10.1101/2020.03.30.20047217v2
Bae, M Kim, et al. Effectiveness of surgical and cotton masks in blocking SARS-CoV-2: A controlled comparison in 4 patients. Ann Int Med. 2020 Apr 6.
https://www.acpjournals.org/doi/10.7326/M20-1342
S Rengasamy, B Eimer, et al. Simple respiratory protection – evaluation of the filtration performance of cloth masks and common fabric materials against 20-1000 nm size particles. Ann Occup Hyg. 2010 Oct; 54(7): 789-798.
https://academic.oup.com/annweh/article/54/7/789/202744
C MacIntyre, H Seale, et al. A cluster randomized trial of cloth masks compared with medical masks in healthcare workers. BMJ Open. 2015; 5(4)
https://bmjopen.bmj.com/content/5/4/e006577.long
W Kellogg. An experimental study of the efficacy of gauze face masks. Am J Pub Health. 1920. 34-42.
https://ajph.aphapublications.org/doi/pdf/10.2105/AJPH.10.1.34
M Klompas, C Morris, et al. Universal masking in hospitals in the Covid-19 era. N Eng J Med. 2020; 382 e63.
https://www.nejm.org/doi/full/10.1056/NEJMp2006372
E Person, C Lemercier et al. Effect of a surgical mask on six minute walking distance. Rev Mal Respir. 2018 Mar; 35(3):264-268.
https://pubmed.ncbi.nlm.nih.gov/29395560/
B Chandrasekaran, S Fernandes. Exercise with facemask; are we handling a devil’s sword – a physiological hypothesis. Med Hypothese. 2020 Jun 22. 144:110002.
https://pubmed.ncbi.nlm.nih.gov/32590322/
P Shuang Ye Tong, A Sugam Kale, et al. Respiratory consequences of N95-type mask usage in pregnant healthcare workers – A controlled clinical study. Antimicrob Resist Infect Control. 2015 Nov 16; 4:48.
https://pubmed.ncbi.nlm.nih.gov/26579222/
T Kao, K Huang, et al. The physiological impact of wearing an N95 mask during hemodialysis as a precaution against SARS in patients with end-stage renal disease. J Formos Med Assoc. 2004 Aug; 103(8):624-628.
https://pubmed.ncbi.nlm.nih.gov/15340662/
Lopp & Edwards reviewed the surgical literature in 2014 and found “no statistically significant difference in infection rates between the masked and unmasked group in any of the trials.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD002929.pub2/full
In a 2014 review based on four studies and 6,006 patients, wrote that “none of the four studies found a difference in the number of post-operative infections whether you used a surgical mask or not.
https://europepmc.org/article/med/25294675
Salassa and Swiontkowski, in 2014, investigated the necessity of scrubs, masks and head coverings in the operating room and concluded that “there is no evidence that these measures reduce the prevalence of surgical site infection
https://journals.lww.com/jbjsjournal/Abstract/2014/09030/Surgical_Attire_and_the_Operating_Room__Role_in.11 .aspx
Da Zhou et al., reviewing the literature in 2015, concluded that “there is a lack of substantial evidence to support claims that facemasks protect either patient or surgeon from infectious contamination.......

Hur f-n ska du ha det?

Går det upp eller ner?

Jag tänker att ett mål bör vara att pressa ner smittspridningen tillräckligt mycket att man minskar virusets utrymme att mutera.

När man inleder vaccinering, så uppstår ett evolutionärt tryck för viruset att ta sig förbi den immunitet som vaccinerna ger. När vaccineringen en gång har inletts, så behöver den därför fortsätta så snabbt som möjligt, för att minska virusets chanser att mutera sig förbi vaccinerna.

När man pressar ner virusets spridning med hjälp av vacciner, så blir det extra viktigt att begränsa resor från länder men mer omfattande smittspridning. Annars kan man få in varianter som tar sig förbi vaccinernas skydd.

Fetat i ditt inlägg av mig.

Viruset muterar hela tiden oavsett om vi vaccinerar eller inte.

Om en livskraftig variant bildas så lever den vidare.
En av dessa mutationer kan, oavsett om vi vaccinerar eller inte, bli motståndskraftig mot vaccinet (eller ett tänkt vaccin som vi inte använder).

Sedan blir det svårare tycker jag.
Hur påverkar egentligen själva vaccinationen hur de olika mutationerna utvecklas?
Givetvis dör en variant som inte kan ta sig förbi immunförsvaret ut.
Den andra varianten som kan ta sig förbi immunförsvaret lever naturligtvis vidare.

Blir det egentligen någon praktisk skillnad om vi vaccinerar eller om vi inte vaccinerar?