Kollade lite kring forskningen över de andra fyra HCoV:s vi har. SARS och MERS kan man faktiskt bortse från då SARS inte spred sig och försvann och MERS inte heller har gjort det. Visste faktiskt inte att t.ex. OC43 var neuroinvasiv d.v.s. angriper hjärnan och CNS. Man misstänker att det viruset kan orsaka neurologiska sjukdomar som MS t.ex. eller åtminstone vara en del av förklaringen. Om det sedan hat att göra med direkt viral infektion eller immunförsvarsreaktion återstår att se:
Neuroinvasion by Human Respiratory Coronaviruses
/..../Given the observations made in animal models, we suggest that coronavirus neurovirulence may also be possible in genetically predisposed human beings, especially for the OC43 strain. Several host factors in humans could influence the outcome of the HCoV CNS infection. Animal models may provide clues for experiments to be performed with human systems. Thus, HCoV can be added to the growing list of viruses that persist in the CNS, a viral flora of the brain that could have pathological consequences in some individuals but remain subclinical and perhaps even beneficial in others.
https://jvi.asm.org/content/74/19/8913/article-info
Så helt ofarliga är de inte. Hur är det då med SARS-CoV-2? Ännu har vi inga definitiva besked; de kommer under hösten enl. uppgift. Min nya hypotes är dock att viruset kommer att följa samma utveckling som de fyra övriga HCoV:s vi har pandemiskt omkring oss. Här har vi en ny artikel i
the Lancet kring det här med neurotropism. Först och främst ser man att smittade tappar lukt och smak även i lindriga fall:
Cerebral Micro-Structural Changes in COVID-19 Patients – An MRI-based 3-month Follow-up Study
Abstract
Background
Increasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We aimed to identify the existence of potential brain micro-structural changes related to SARS-CoV-2.
/.../
Findings
In this follow-up stage, neurological symptoms were presented in 55% COVID-19 patients. COVID-19 patients had statistically significantly higher bilateral gray matter volumes (GMV) in olfactory cortices, hippocampi, insulas, left Rolandic operculum, left Heschl's gyrus and right cingulate gyrus and a general decline of MD, AD, RD accompanied with an increase of FA in white matter, especially AD in the right CR, EC and SFF, and MD in SFF compared with non-COVID-19 volunteers (corrected p value <0.05). Global GMV, GMVs in left Rolandic operculum, right cingulate, bilateral hippocampi, left Heschl's gyrus, and Global MD of WM were found to correlate with memory loss (p value <0.05). GMVs in the right cingulate gyrus and left hippocampus were related to smell loss (p value <0.05). MD-GM score, global GMV, and GMV in right cingulate gyrus were correlated with LDH level (p value <0.05).
Interpretation
Study findings revealed possible disruption to micro-structural and functional brain integrity in the recovery stages of COVID-19, suggesting the long-term consequences of SARS-CoV-2.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30228-5/fulltext#seccesectitle0032
Men äsch, det är ju bara en förkylning!
