Citat:
Har tittat runt angående hydroxyklorokin och huruvida det funderar. Det verkar fungera dåligt och tillsammans med azitromycin kan det t.o.m. förvärra förloppet. Jag har dock sett andra undersökningar där man har noterat en marginell förbättring hos patienter med lindriga symptom. Här är studien med lite mer avancerade fall:
No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection
Dr Gaetan Burgio, MD, PhD.
@GaetanBurgio
No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection
/.../In summary, despite a reported antiviral activity of chloroquine against COVID-19 in vitro, weLite fler kommentarer:
found no evidence of a strong antiviral activity or clinical benefit of the combination of
hydroxychloroquine and azithromycin for the treatment of our hospitalized patients with
severe COVID-19. Ongoing randomized clinical trials with hydroxychloroquine should provide
a definitive answer regarding the alleged efficacy of this combination and will assess its safety.
Dr Gaetan Burgio, MD, PhD.
@GaetanBurgio
Another report on Hydroxychloroquine and Azithromycin treatment on 11 patients with severe #COVID19 in ID department St Louis Hospital, Paris -> prospective study, not a clinical trial & follow up from the French trial. Let's have a lookhttps://threadreaderapp.com/thread/1245472218215149568.html
No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection11 patients 7 men, 4 women, ~ 58 years 8 with co-morbidity (cancer, HIV, obesity). Hospitalized in ID department with O2 treatment for COVID19 pneumonia -> Treated with 600 mg HCQ/day for 10 days & 500 mg AZ day 1 and 250 mg days 2 to 5
https://www.sciencedirect.com/science/article/pii/S0399077X20300858
Outcome: pretty terrible. 1 died, 1 transferred to ICU, one treatment discontinued because of increased in QT at day 4. Rest nothing changed clinically and viral load was unchanged without resolution of the infection . HCQ dose was 678 ng/ml (381-891) 7 days post treatment
In short no changes in clinical and viral load in those patients that have received HCQ + AZ. Despite low number and not being randomized, so far HCQ and AZ treatment aggravate the clinical outcome, not improve it.
From the various reports and trial on HCQ treatment for #COVID19, HCQ might give a modest improvement for non severe #COVID19 cases. For #COVID19 severe cases HCQ + AZ seems useless and gives more side effects than anything else.
Again multi centric and large scale randomized clinical trial will enable to ascertain wether or not HCQ and AZ treatment is efficacious against #COVID19. since then, there will be series of small scale studies published with contradictory results.
Thanks @TaschnerNatalia for sending me the link to this study !
Tusen tack att du tog dig tid att gräva fram detta!
Viktigare än någonsin att FHM förbjuds att utöka experimentet med den svenska befolkningen. Inte långsökt att tänka sig att myndigheten försöker skyla över sin inkompetens, a la Macciarini, genom låtsad handlingskraft (som i förlängningen resulterar i fler döda).
Låt inte Tegnell komma undan med mummel om att detta verkar fungera bra. Viktigare än någonsin att journalisterna är pålästa så att de kan lyfta fram och ifrågasätta rena lögner.