Citat:
Ursprungligen postat av
EliasAlucard
Menar du att cannabinoider inte är bra för immunförsvaret?
Abstract
Since the discovery of the cannabinoid receptors and their endogenous ligands, significant advances have been made in studying the physiological function of the endocannabinoid system. The presence of cannabinoid receptors on cells of the immune system and anecdotal and historical evidence suggesting that cannabis use has potent immuno-modulatory effects, has led to research directed at understanding the function and role of these receptors within the context of immunological cellular function. Studies from chronic cannabis smokers have provided much of the evidence for immunomodulatory effects of cannabis in humans, and animal and in vitro studies of immune cells such as T cells and macrophages have also provided important evidence. Cannabinoids can modulate both the function and secretion of cytokines from immune cells. Therefore, cannabinoids may be considered for treatment of inflammatory disease. This review article will highlight recent research on cannabinoids and how they interact with the immune system and also their potential use as therapeutic agents for a number of inflammatory disorders.
Cannabinoids and the Immune System: Potential for the Treatment of Inflammatory Diseases?
https://pubmed.ncbi.nlm.nih.gov/16023222/
Samt:
Abstract
Cannabinoids can influence the immune network. Data on the impact of exogenous cannabinoid ligands on immune function serve not only to understand how the endocannabinoid system modulates immune phenomena associated with infection or inflammation, but also to identify therapeutic targets for immune diseases. Cannabinoids can modulate immune reactions in the periphery but also in the brain, influence T cell subset balance and cytokine expression and play a role in the balance between neuroinflammation and neurodegeneration. Immune cells can synthesize endocannabinoids and also be influenced by cannabinoid analogues. Cannabinoid receptors show different expression on immune cells depending on activation status and stimuli. The complexity of relation between cannabinoid ligands of various classes and cannabinoid receptors brought the need to refine the simple conceptual frame of agonist-antagonists and offered potential implications for understanding interactions in pathological conditions. The immune influence of cannabinoid ligands is not fully elucidated. However, aspects of their immunomodulatory effects provide the basis for a context-dependent targeted therapeutic approach, thus leading to the possibility for the use of cannabinoids in the treatment of inflammatory disease.
Cannabinoids and the Immune System: An Overview
https://pubmed.ncbi.nlm.nih.gov/20153077/
Låter helt klart som att medicinsk marijuana kan förbättra immunförsvaret hos COVID-19 patienter om du frågar mig.
Jag kan nästan garantera dig att man skulle kunna uppmäta en massa effekter på T-celler av Klorin också. Det betyder inte att det nödvändigtvis förbättrar immunförsvaret.
Immunförsvaret är enormt komplicerat och innehåller en massa regleringar hit och dit eftersom det alltid är en balansgång att få en lagom effekt.
Att det skulle finnas nån jätteenkel lösning där lite kemiska substanser från en planta ger en stor förbättring utan risker är rätt osannolikt. Fanns det nåt enkelt steg i någon process som gjorde allt bättre skulle hundratals miljoner år av evolution redan fixat det.
En tryckluftsspruta från biltema full av budgetfärg skulle ha en massa effekter i sixtinska kapellet men Nattvarden skulle sannolikt inte bli ett mer fulländat konstverk av att man sprutmålade skiten lite på måfå här och där.
