Som rubriken lyder så Vad är egentligen bretazenil såg att någon la ut ett inlägg för ca en vecka sedan men det togs bort så startar en ny tråd . Det här hittar jag på wikipedia verkar som att den nslår på samtliga gabareceptorer. Anledningen till nyfiuoikenheten är att den finns inne på en svensk inrikesshop både i 1 mg kapslar och Vial (vätska). Att den ska vara lik Flumazenil säger mig inte mycket det heller då flumazenil väl är till för att häva en bensoöverdos?
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the GABA antagonist flumazenil, although its effects are somewhat different.
It is classified as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist.
Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome. Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.
https://en.wikipedia.org/wiki/Bretazenil
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the GABA antagonist flumazenil, although its effects are somewhat different.
It is classified as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist.
Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome. Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.
https://en.wikipedia.org/wiki/Bretazenil
Okej, jag börjar känna mig lite påverkad. Jag uppdaterar mer senare. Sammanfattningsvis känns den trevlig och med subtil men ändå klart märkbar effekt, jag skulle säga att Oxascand är det som ligger närmast.